TRAIL Enhances Shikonin Induced Apoptosis through ROS/JNK Signaling in Cholangiocarcinoma Cells | Zendy

Guangyao Zhou | Zendy; Zuqin Yang | Zendy; Xiaodong Wang | Zendy; Ran Tao | Zendy; Yuanping Zhou | Zendy

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TRAIL Enhances Shikonin Induced Apoptosis through ROS/JNK Signaling in Cholangiocarcinoma Cells

Author(s) -

Guangyao Zhou,

Zuqin Yang,

Xiaodong Wang,

Ran Tao,

Yuanping Zhou

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000478758

Subject(s) - apoptosis , viability assay , protein kinase b , mtt assay , chemistry , cancer research , flow cytometry , downregulation and upregulation , signal transduction , biology , microbiology and biotechnology , biochemistry , gene

Cholangiocarcinoma (CCA), arising from varying locations within the biliary tree, is the second most common primary liver malignancy worldwide. Shikonin, an active compound extracted from the Chinese herb Zicao, holds anti-bacterial, anti-inflammatory, and anti-tumor activities. However, the effect of shikonin on human cholangiocarcinoma and detailed mechanisms of TRAIL enhancement remains to be elucidated. The purpose of the study was to investigate the protective functions of TRAIL enhancement for shikonin induced apoptosis in cholangiocarcinoma cells.

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