Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells | Zendy

Yingjuan Yang | Zendy; Yanhua Zhang | Zendy; Lan Wang | Zendy; Shaochin Lee | Zendy

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Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells

Author(s) -

Yingjuan Yang,

Yanhua Zhang,

Lan Wang,

Shaochin Lee

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000478647

Subject(s) - apoptosis , viability assay , unfolded protein response , reactive oxygen species , mtt assay , cancer cell , cancer , colorectal cancer , cancer research , flow cytometry , programmed cell death , endoplasmic reticulum , blot , chemistry , biology , microbiology and biotechnology , biochemistry , genetics , gene

Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Levistolide A (LA), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is used for treating cancer. In this study, we investigated the anticancer effect of LA in HCT116 and its isogenic p53-/- colon cancer cells, as well as the underlying mechanisms.

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