The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis | Zendy

Bangwei Wu | Zendy; Huanchun Ni | Zendy; Jian Li | Zendy; Xinyu Zhuang | Zendy; Jinjin Zhang | Zendy; Zhiyong Qi | Zendy; Qiying Chen | Zendy; Zhichao Wen | Zendy; Haiming Shi | Zendy; Xinping Luo | Zendy; Bo Jin | Zendy

Open Access

The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis

Author(s) -

Bangwei Wu,

Huanchun Ni,

Jian Li,

Xinyu Zhuang,

Jinjin Zhang,

Zhiyong Qi,

Qiying Chen,

Zhichao Wen,

Haiming Shi,

Xinping Luo,

Bo Jin

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000477889

Subject(s) - inflammation , tlr4 , myocarditis , tlr9 , apoptosis , lipopolysaccharide , immune system , immunology , medicine , biology , cancer research , gene expression , gene , biochemistry , dna methylation

Mitochondrial DNA (mtDNA), acting as a newly found 'danger-associated molecular patterns' (DAMPs), is released into circulation upon tissue injury and performs as a considerable activator of inflammation and immune response. However, the role of circulating mtDNA in experimental autoimmune myocarditis (EAM) as well as Toll like receptor4 (TLR4) mediated cardiac inflammation and injury remains unknown.

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