Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway | Zendy

Xiaoxv Dong | Zendy; Jing Fu | Zendy; Xingbin Yin | Zendy; Changhai Qu | Zendy; Chunjing Yang | Zendy; Huyiligeqi He | Zendy; Jian Ni | Zendy

Open Access

Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway

Author(s) -

Xiaoxv Dong,

Jing Fu,

Xingbin Yin,

Changhai Qu,

Chunjing Yang,

Huyiligeqi He,

Jian Ni

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000477886

Subject(s) - reactive oxygen species , apoptosis , aloe emodin , microbiology and biotechnology , mitochondrion , cell culture , chemistry , biology , emodin , biochemistry , genetics

Aloe-emodin (1,8-dihydroxy-3-hydroxymethyl-anthraquinone), an anthraquinone active compounds, is isolated from some traditional medicinal plants such as Rheum palmatum L. and Cassia occidentalis, which induce hepatotoxicity in rats. The aim of this study was to determine potential cytotoxic effects of aloe-emodin on HepaRG cells and to define the underlying mechanism.

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