Age-Related Insulin-Like Growth Factor Binding Protein-4 Overexpression Inhibits Osteogenic Differentiation of Rat Mesenchymal Stem Cells | Zendy

Jinhui Wu | Zendy; Chao Wang | Zendy; Miao Xiong | Zendy; Yungang Wu | Zendy; Jiabin Yuan | Zendy; Muchen Ding | Zendy; Jingfeng Li | Zendy; Zhi-Cai Shi | Zendy

Open Access

Age-Related Insulin-Like Growth Factor Binding Protein-4 Overexpression Inhibits Osteogenic Differentiation of Rat Mesenchymal Stem Cells

Author(s) -

Jinhui Wu,

Chao Wang,

Miao Xiong,

Yungang Wu,

Jiabin Yuan,

Muchen Ding,

Jingfeng Li,

Zhi-Cai Shi

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000477873

Subject(s) - runx2 , osteocalcin , mesenchymal stem cell , osteoblast , gene knockdown , smad , bone morphogenetic protein 2 , microbiology and biotechnology , chemistry , downregulation and upregulation , endocrinology , alkaline phosphatase , cellular differentiation , medicine , cancer research , biology , signal transduction , apoptosis , biochemistry , in vitro , gene , enzyme

Insulin-like growth factor binding proteins (IGFBP) play important roles in bone metabolism. IGFBP4 is involved in senescent-associated phenomena in mesenchymal stem cells (MSCs). The goal of the present study was to determine whether age-related IGFBP4 overexpression is associated with the impaired osteogenic differentiation potential of aged bone marrow derived MSCs.

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