Molecular Imaging of Inducible VEGF Expression and Tumor Progression in a Breast Cancer Model | Zendy

Liang Lu | Zendy; Zhiwei Yue | Zendy; Wei Du | Zendy; Yang Li | Zendy; Hongyan Tao | Zendy; Di Wang | Zendy; Ran Wang | Zendy; Ziwei Huang | Zendy; Ningning He | Zendy; Xiaoyan Xie | Zendy; Zhongchao Han | Zendy; Na Liu | Zendy; Zongjin Li | Zendy

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Molecular Imaging of Inducible VEGF Expression and Tumor Progression in a Breast Cancer Model

Author(s) -

Liang Lu,

Zhiwei Yue,

Wei Du,

Yang Li,

Hongyan Tao,

Di Wang,

Ran Wang,

Ziwei Huang,

Ningning He,

Xiaoyan Xie,

Zhongchao Han,

Na Liu,

Zongjin Li

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000477485

Subject(s) - autocrine signalling , paracrine signalling , angiogenesis , bioluminescence imaging , vascular endothelial growth factor , cancer research , vascular endothelial growth factor a , hif1a , cancer , neovascularization , biology , pathology , medicine , cell culture , luciferase , transfection , vegf receptors , genetics , receptor

Tumor derived vascular endothelial growth factor (VEGF) can stimulate proliferation and migration of endothelial cells and recruit endothelial progenitor cells into tumors for vascular formation via a paracrine manner. Now increasing evidence suggests that VEGF also serves as an autocrine factor promoting cell survival and tumor angiogenesis. Real time visualization of VEGF activity in the early stages of tumor formation using molecular imaging will provide unprecedented insight into the biological processes of cancer.

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