Losartan Preserves Erectile Function by Suppression of Apoptosis and Fibrosis of Corpus Cavernosum and Corporal Veno-Occlusive Dysfunction in Diabetic Rats | Zendy

Wen Ji Li | Zendy; Mingxi Xu | Zendy; Meng Gu | Zendy; Dachao Zheng | Zendy; Jianhua Guo | Zendy; Zhikang Cai | Zendy; Zhong Wang | Zendy

Open Access

Losartan Preserves Erectile Function by Suppression of Apoptosis and Fibrosis of Corpus Cavernosum and Corporal Veno-Occlusive Dysfunction in Diabetic Rats

Author(s) -

Wen Ji Li,

Mingxi Xu,

Meng Gu,

Dachao Zheng,

Jianhua Guo,

Zhikang Cai,

Zhong Wang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000477388

Subject(s) - losartan , erectile dysfunction , medicine , fibrosis , sildenafil , endocrinology , angiotensin ii , apoptosis , smad , transforming growth factor , urology , blood pressure , chemistry , biochemistry

Transforming growth factor-β1 (TGF-β1) plays important roles in penile corporal fibrosis and veno-occlusive dysfunction (CVOD). Angiotensin II (Ang II) is critically involved in erectile dysfunction, and blocking of Ang II is more important than inhibition of TGF-β in non-penile tissue fibrosis. However, the role of Ang II in corporal fbrosis and CVOD in a diabetic condition has not been investigated.

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