Transient Receptor Potential Vanilloid 5 Mediates Ca2+ Influx and Inhibits Chondrocyte Autophagy in a Rat Osteoarthritis Model | Zendy

Yingliang Wei | Zendy; Yanfang Wang | Zendy; Yutong Wang | Zendy; Lunhao Bai | Zendy

Open Access

Transient Receptor Potential Vanilloid 5 Mediates Ca2+ Influx and Inhibits Chondrocyte Autophagy in a Rat Osteoarthritis Model

Author(s) -

Yingliang Wei,

Yanfang Wang,

Yutong Wang,

Lunhao Bai

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000477387

Subject(s) - autophagy , chondrocyte , calmodulin , chemistry , western blot , transient receptor potential channel , microbiology and biotechnology , phosphorylation , small interfering rna , blot , kinase , receptor , transfection , calcium , biology , biochemistry , apoptosis , in vitro , organic chemistry , gene

Autophagy, a self-protective mechanism of chondrocytes, has become a promising target to impede the progress of osteoarthritis (OA). Autophagy is regulated by cytosolic Ca2+ activity and may thus be modified by the Ca2+ permeable transient receptor potential channel vanilloid 5 (TRPV5). Therefore, we investigated the potential role of TRPV5 in mediating Ca2+ influx and in inhibiting chondrocyte autophagy in a rat OA model.

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