Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma | Zendy

Bettina Hieronimus | Zendy; Julian Pfohl | Zendy; Christian Busch | Zendy; Lutz Graeve | Zendy

Open Access

Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma

Author(s) -

Bettina Hieronimus,

Julian Pfohl,

Christian Busch,

Lutz Graeve

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000477311

Subject(s) - matrix metalloproteinase , furin , biology , microbiology and biotechnology , cell culture , biochemistry , genetics , enzyme

Membrane-type matrix metalloproteinases (MT-MMPs) are expressed on the cell surface and hydrolyze extracellular matrix components and signaling molecules by which they influence cancer cell migration and metastasis. Two of the six known MT-MMPs are anchored to the plasma membrane via a GPI anchor, one of which is MT4-MMP. Only little is known about MT4-MMP expression, synthesis, regulation and degradation.

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