Ex vivo Generation of Genetically Modified Macrophages from Human Induced Pluripotent Stem Cells | Zendy

Mania Ackermann | Zendy; Alexandra Kuhn | Zendy; Jessica Kunkiel | Zendy; Sylvia Merkert | Zendy; Ulrich Martin | Zendy; Thomas Moritz | Zendy; Nico Lachmann | Zendy

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Ex vivo Generation of Genetically Modified Macrophages from Human Induced Pluripotent Stem Cells

Author(s) -

Mania Ackermann,

Alexandra Kuhn,

Jessica Kunkiel,

Sylvia Merkert,

Ulrich Martin,

Thomas Moritz,

Nico Lachmann

Publication year - 2017

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000477129

Subject(s) - induced pluripotent stem cell , transgene , biology , viral vector , microbiology and biotechnology , stem cell , embryonic stem cell , genetics , gene , recombinant dna

Pluripotent stem cells, including induced pluripotent stem cells (iPSCs), have the capacity to differentiate towards all three germ layers and have been highlighted as an attractive cell source for the field of regenerative medicine. Thus, stable expression of therapeutic transgenes in iPSCs, as well as thereof derived progeny of hematopoietic lineage, may lay the foundation for innovative cell replacement therapies.

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