Resveratrol Protects Against Pulmonary Arterial Hypertension in Rats via Activation of Silent Information Regulator 1 | Zendy

Lei Yu | Zendy; Yingfeng Tu | Zendy; Xueling Jia | Zendy; Kun Fang | Zendy; Li Liu | Zendy; Lin Wan | Zendy; Chuanying Xiang | Zendy; Yanan Wang | Zendy; Sun Xiang-ju | Zendy; Tianyou Liu | Zendy; Dejun Yu | Zendy; Weiwei Cao | Zendy; Yinli Song | Zendy; Yuhua Fan | Zendy

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Resveratrol Protects Against Pulmonary Arterial Hypertension in Rats via Activation of Silent Information Regulator 1

Author(s) -

Lei Yu,

Yingfeng Tu,

Xueling Jia,

Kun Fang,

Li Liu,

Lin Wan,

Chuanying Xiang,

Yanan Wang,

Sun Xiang-ju,

Tianyou Liu,

Dejun Yu,

Weiwei Cao,

Yinli Song,

Yuhua Fan

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000477115

Subject(s) - resveratrol , apoptosis , right ventricular hypertrophy , tunel assay , hypoxia (environmental) , pulmonary hypertension , ventricular pressure , vascular remodelling in the embryo , pulmonary artery , pharmacology , flow cytometry , mitochondrial permeability transition pore , western blot , medicine , endocrinology , chemistry , biology , blood pressure , immunology , programmed cell death , biochemistry , organic chemistry , oxygen , gene

The polyphenol resveratrol (Rev) has been found to exhibit various beneficial effects including prevention of pulmonary arterial hypertension (PAH). The present study was designed to investigate the action and potential mechanism of Rev on PAH, focusing on the role of SIRT1 (Silent Information Regulator 1) in apoptosis of pulmonary artery smooth muscle cells (PASMCs).

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