Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins | Zendy

Jessyca Sousa de Brito | Zendy; Natália Alvarenga Borges | Zendy; Marta Esgalhado | Zendy; D’Angelo Carlo Magliano | Zendy; Christophe O. Soulage | Zendy; Denise Mafra | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins

Author(s) -

Jessyca Sousa de Brito,

Natália Alvarenga Borges,

Marta Esgalhado,

D’Angelo Carlo Magliano,

Christophe O. Soulage,

Denise Mafra

Publication year - 2017

Publication title -

the nephron journals/nephron journals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.951

H-Index - 72

eISSN - 2235-3186

pISSN - 1660-8151

DOI - 10.1159/000476074

Subject(s) - aryl hydrocarbon receptor , uremic toxins , kidney disease , uremia , mediator , inflammation , chemistry , receptor , proinflammatory cytokine , transcription factor , kidney , biology , biochemistry , medicine , endocrinology , immunology , gene

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in the expression of xenobiotic-metabolizing enzymes, inflammatory cytokines and adhesion molecules. Uremic toxins such as indoxyl sulfate and indole acetic acid are derived from tryptophan fermentation by gut microbiota; they accumulate in patients with chronic kidney disease (CKD) on haemodialysis and have recently emerged as potent ligands of AhR. Therefore, AhR can serve as a mediator in inflammation and cardiovascular diseases in these patients. This review discusses current data that support a link between AhR activation and uremic toxins from gut microbiota in CKD.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research