The Long Non-Coding RNA CRNDE Promotes Colorectal Carcinoma Progression by Competitively Binding miR-217 with TCF7L2 and Enhancing the Wnt/β-Catenin Signaling Pathway | Zendy

Bo Yu | Zendy; Xuan Ye | Zendy; Qiong Du | Zendy; Bin Zhu | Zendy; Qing Zhai | Zendy

Open Access

The Long Non-Coding RNA CRNDE Promotes Colorectal Carcinoma Progression by Competitively Binding miR-217 with TCF7L2 and Enhancing the Wnt/β-Catenin Signaling Pathway

Author(s) -

Bo Yu,

Xuan Ye,

Qiong Du,

Bin Zhu,

Qing Zhai

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000475941

Subject(s) - wnt signaling pathway , cancer research , microrna , colorectal cancer , cell growth , long non coding rna , blot , signal transduction , biology , catenin , chemistry , cancer , downregulation and upregulation , microbiology and biotechnology , gene , biochemistry , genetics

The long non-coding RNA colorectal neoplasia differentially expressed (CRNDE) contributes to the proliferation and migration of tumors. However, its molecular mechanism underlying gastric cancer remains unknown. In the present study, we investigated whether CRNDE was involved in the development of colorectal cancer via the binding of microRNA (miR)-217 with transcription factor 7-like 2 (TCF7L2) to enhance the Wnt signaling pathway.

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