Open AccessExamining the Causal Role of Leptin in Alzheimer Disease: A Mendelian Randomization Study
Author(s) -
Matthew L. Romo,
C. Mary Schooling
Publication year - 2017
Publication title -
neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.493
H-Index - 101
eISSN - 1423-0194
pISSN - 0028-3835
DOI - 10.1159/000475713
Subject(s) - mendelian randomization , leptin , medicine , single nucleotide polymorphism , endocrinology , leptin receptor , biology , genome wide association study , confidence interval , odds ratio , genetics , genotype , obesity , gene , genetic variants
Observational evidence regarding the role of leptin in Alzheimer disease (AD) is conflicting. We sought to determine the causal role of circulating leptin and soluble plasma leptin receptor (sOB-R) levels in AD using a separate-sample Mendelian randomization study.
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