Inhibition of Suicidal Erythrocyte Death by Reversine | Zendy

Mohamed Jèmaà | Zendy; Myriam Fezai | Zendy; Florian Läng | Zendy

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Inhibition of Suicidal Erythrocyte Death by Reversine

Author(s) -

Mohamed Jèmaà,

Myriam Fezai,

Florian Läng

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000475654

Subject(s) - ionomycin , annexin , oxidative stress , apoptosis , chemistry , microbiology and biotechnology , programmed cell death , phosphatidylserine , annexin a5 , mitochondrion , oxidative phosphorylation , biophysics , biology , intracellular , biochemistry , phospholipid , membrane

The A3 adenosine receptor antagonist reversine (2-(4-morpholinoanilino)-6-cyclohexylaminopurine) influences cellular differentiation, inhibits cell proliferation, induces cell-cycle arrest, triggers apoptosis, causes cell swelling with polyploidy and stimulates autophagy. The effect on apoptosis involves mitochondria and caspases. Erythrocytes are lacking mitochondria but express caspases and are, similar to apoptosis of nucleated cells, able to enter suicidal erythrocyte death or eryptosis. Stimulators of eryptosis include increase of cytosolic Ca2+ activity ([Ca2+]i), energy depletion and oxidative stress. The present study explored, whether reversine influences eryptosis.

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