Inhibition of Colon Carcinoma Cell Migration Following Treatment with Purified Venom from Lesser Weever Fish (Trachinus Vipera) | Zendy

Myriam Fezai | Zendy; Chaker Slaymi | Zendy; Mossadok BenAttia | Zendy; Guido Kroemer | Zendy; Florian Läng | Zendy; Mohamed Jèmaà | Zendy

Open Access

Inhibition of Colon Carcinoma Cell Migration Following Treatment with Purified Venom from Lesser Weever Fish (Trachinus Vipera)

Author(s) -

Myriam Fezai,

Chaker Slaymi,

Mossadok BenAttia,

Guido Kroemer,

Florian Läng,

Mohamed Jèmaà

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000475646

Subject(s) - apoptosis , cell , cell migration , flow cytometry , necrosis , programmed cell death , venom , biology , cell growth , microbiology and biotechnology , chemistry , pathology , medicine , biochemistry

Injury by the sting of Lesser weever fish (Trachinus vipera) may lead to severe pain, edema or tissue necrosis. Cellular effects of the venom are still incompletely understood. Previous observations revealed that purified Lesser weever fish venom (LWFV) induces suicidal death of erythrocytes and HCT116 human colon carcinoma cells. The present study addressed the effect of the venom on colon carcinoma cell toxicity, shape and migration both in p53+/+ and/or p53-/- conditions.

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