Comparison of the Skin Penetration of 3 Metabolically Stable Chemicals Using Fresh and Frozen Human Skin | Zendy

Carine Jacques | Zendy; Hélène Duplan | Zendy; Helga Rothe | Zendy; Ophelie Vaillant | Zendy; Joan Eilstein | Zendy; Sébastien Grégoire | Zendy; Richard Cubberley | Zendy; Daniela Lange | Zendy; Corie A. Ellison | Zendy; Martina Klarić | Zendy; Nicola J. Hewitt | Zendy; Andreas Schepky | Zendy

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Comparison of the Skin Penetration of 3 Metabolically Stable Chemicals Using Fresh and Frozen Human Skin

Author(s) -

Carine Jacques,

Hélène Duplan,

Helga Rothe,

Ophelie Vaillant,

Joan Eilstein,

Sébastien Grégoire,

Richard Cubberley,

Daniela Lange,

Corie A. Ellison,

Martina Klarić,

Nicola J. Hewitt,

Andreas Schepky

Publication year - 2017

Publication title -

skin pharmacology and physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.703

H-Index - 74

eISSN - 1660-5535

pISSN - 1660-5527

DOI - 10.1159/000475472

Subject(s) - penetration (warfare) , chemistry , human skin , biochemistry , biology , genetics , operations research , engineering

The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whether the storage of human skin used in our studies (8-12 weeks at -20°C) affected the penetration of model chemicals.

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