Effects of Estradiol on Autophagy and Nrf-2/ARE Signals after Cerebral Ischemia | Zendy

Litao Li | Zendy; Jinghong Chen | Zendy; Sujuan Sun | Zendy; Jingru Zhao | Zendy; Xiaoli Dong | Zendy; Jianhua Wang | Zendy

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Effects of Estradiol on Autophagy and Nrf-2/ARE Signals after Cerebral Ischemia

Author(s) -

Litao Li,

Jinghong Chen,

Sujuan Sun,

Jingru Zhao,

Xiaoli Dong,

Jianhua Wang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000475433

Subject(s) - autophagy , neuroprotection , oxidative stress , ischemia , western blot , inflammation , signal transduction , hippocampus , programmed cell death , microbiology and biotechnology , medicine , biology , pharmacology , neuroscience , apoptosis , biochemistry , gene

Estradiol (EST) reduces the risk of stroke and decreases the incidence and progression of the disease because of its neuroprotective roles in inhibiting cell death that occurs in response to a variety of neuronal stimuli such as inflammation and oxidative stress. In this study, we determined the role played by autophagy and Nrf2-ARE signal pathways in the hippocampus regions in modulating cerebral ischemia under different EST conditions.

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