Open AccessMiR-34a Promotes Apoptosis and Inhibits Autophagy by Targeting HMGB1 in Acute Myeloid Leukemia Cells
Author(s) -
Liru Liu,
Weihua Ren,
Kuisheng Chen
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000475277
Subject(s) - autophagy , apoptosis , myeloid leukemia , transfection , lipofectamine , cancer research , hmgb1 , biology , flow cytometry , western blot , microbiology and biotechnology , cell culture , chemistry , immunology , gene , biochemistry , recombinant dna , genetics , vector (molecular biology) , inflammation
MiR-34a is identified as a tumor suppressor gene and involved in acute myeloid leukemia (AML) development. However, the regulatory mechanism of miR-34a in AML is unclear.
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