LincRNA-p21 Inhibits the Wnt/β-Catenin Pathway in Activated Hepatic Stellate Cells via Sponging MicroRNA-17-5p | Zendy

Fujun Yu | Zendy; Yong Guo | Zendy; Bicheng Chen | Zendy; Liang Shi | Zendy; Peihong Dong | Zendy; Mengtao Zhou | Zendy; Jianjian Zheng | Zendy

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LincRNA-p21 Inhibits the Wnt/β-Catenin Pathway in Activated Hepatic Stellate Cells via Sponging MicroRNA-17-5p

Author(s) -

Fujun Yu,

Yong Guo,

Bicheng Chen,

Liang Shi,

Peihong Dong,

Mengtao Zhou,

Jianjian Zheng

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000472410

Subject(s) - hepatic stellate cell , wnt signaling pathway , microrna , catenin , microbiology and biotechnology , cancer research , chemistry , biology , signal transduction , endocrinology , gene , biochemistry

It is known that the activation of hepatic stellate cells (HSCs) is a pivotal step in the initiation and progression of liver fibrosis. Aberrant activated Wnt/β-catenin pathway is known to accelerate the development of liver fibrosis. microRNAs (miRNAs)-mediated Wnt/β-catenin pathway has been reported to be involved in HSC activation during liver fibrosis. However, whether long noncoding RNAs (lncRNAs) regulate Wnt/β-catenin pathway during HSC activation still remains unclear.

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