MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1 | Zendy

Lin Fan | Zendy; Chunyan Zhu | Zendy; Rongmin Qiu | Zendy; Pengfei Zan | Zendy; Zhi Zheng | Zendy; Tian-Yang Xu | Zendy; Guodong Li | Zendy

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MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1

Author(s) -

Lin Fan,

Chunyan Zhu,

Rongmin Qiu,

Pengfei Zan,

Zhi Zheng,

Tian-Yang Xu,

Guodong Li

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000472380

Subject(s) - apoptosis , osteosarcoma , microrna , microbiology and biotechnology , cytochrome c , cell , cancer research , biology , chemistry , mitochondrion , gene , biochemistry

Osteosarcoma (OS) is an aggressive bone malignancy that affects rapidly growing bones and is associated with a poor prognosis. Our previous study showed that cytochrome c1 (CYC1), a subunit of the cytochrome bc1 complex (complex III) of the mitochondrial electron chain, is overexpressed in human OS tissues and cell lines and its silencing induces apoptosis in vitro and inhibits tumor growth in vivo. Here, we investigated the mechanism underlying the modulation of CYC1 expression in OS and its role in the resistance of OS to apoptosis.

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