Osteopontin Promotes Cell Migration and Invasion, and Inhibits Apoptosis and Autophagy in Colorectal Cancer by activating the p38 MAPK Signaling Pathway | Zendy

Renhong Huang | Zendy; Yingjun Quan | Zendy; Jinhong Chen | Zendy; Tingfeng Wang | Zendy; Ming Xu | Zendy; Min Ye | Zendy; Hao Yuan | Zendy; Chongjie Zhang | Zendy; Xiaojian Liu | Zendy; Zhijun Min | Zendy

Open Access

Osteopontin Promotes Cell Migration and Invasion, and Inhibits Apoptosis and Autophagy in Colorectal Cancer by activating the p38 MAPK Signaling Pathway

Author(s) -

Renhong Huang,

Yingjun Quan,

Jinhong Chen,

Tingfeng Wang,

Ming Xu,

Min Ye,

Hao Yuan,

Chongjie Zhang,

Xiaojian Liu,

Zhijun Min

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000471933

Subject(s) - autophagy , osteopontin , apoptosis , cell growth , cell migration , cell , microbiology and biotechnology , mapk/erk pathway , cell cycle , western blot , cancer research , carcinogenesis , p38 mitogen activated protein kinases , biology , flow cytometry , chemistry , signal transduction , cancer , immunology , biochemistry , genetics , gene

Osteopontin (OPN) is highly expressed in colorectal cancer (CRC) and is associated with disease progression in vivo. High levels of OPN have been demonstrated to predict low survival rates in CRC. Autophagy is a process of self-digestion, which is thought to play a significant role in carcinogenesis. However, the mechanisms of OPN's effects on CRC cell autophagy have not been elucidated. Therefore, we aimed to investigate possible mechanisms of OPN's effects on CRC autophagy.

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