(-)-Epigallocatechin-3-Gallate Inhibits Arsenic-Induced Inflammation and Apoptosis through Suppression of Oxidative Stress in Mice | Zendy

Nanhui Yu | Zendy; Haiping Pei | Zendy; Yongpan Huang | Zendy; Yufei Li | Zendy

Open Access

(-)-Epigallocatechin-3-Gallate Inhibits Arsenic-Induced Inflammation and Apoptosis through Suppression of Oxidative Stress in Mice

Author(s) -

Nanhui Yu,

Haiping Pei,

Yongpan Huang,

Yufei Li

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000471911

Subject(s) - oxidative stress , superoxide dismutase , reactive oxygen species , chemistry , glutathione , apoptosis , catalase , inflammation , pharmacology , immunology , biochemistry , biology , enzyme

Exposure to arsenic in individuals has been found to be associated with various health-related problems including skin lesions, cancer, and cardiovascular and immunological disorders. (-)-Epigallocatechin-3-gallate (EGCG), the main and active polyphenolic catechin present in green tea, has shown potent antioxidant, anti-apoptotic and anti-inflammatory activity in vivo and in vitro. Thus, the present study was conducted to investigate the protective effects of EGCG against arsenic-induced inflammation and immunotoxicity in mice.

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