Akt2-Dependent Beneficial Effect of Galanin on Insulin-Induced Glucose Uptake in Adipocytes of Diabetic Rats | Zendy

Zhenwen Zhang | Zendy; Penghua Fang | Zendy; Lili Guo | Zendy; Biao He | Zendy; Mingyi Shi | Zendy; Yan Zhu | Zendy; Ping Bo | Zendy

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Akt2-Dependent Beneficial Effect of Galanin on Insulin-Induced Glucose Uptake in Adipocytes of Diabetic Rats

Author(s) -

Zhenwen Zhang,

Penghua Fang,

Lili Guo,

Biao He,

Mingyi Shi,

Yan Zhu,

Ping Bo

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000471870

Subject(s) - glut4 , medicine , galanin , endocrinology , akt2 , insulin , glucose transporter , glucose uptake , protein kinase b , chemistry , glycogen synthase , adipocyte , phosphorylation , biology , adipose tissue , neuropeptide , receptor , biochemistry , akt1

Glucose uptake occurs via the activation of an insulin-signaling cascade, resulting in the translocation of glucose transporter 4 (GLUT4) to the plasma membrane of adipocytes and myocytes. Recent research found that galanin could boost insulin-induced glucose uptake. This study aimed to explore whether activation of Akt2 mediates the beneficial effects of galanin on insulin-induced glucose uptake in the adipocytes of diabetic rats.

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