Dickkopf-Related Protein 2 is Epigenetically Inactivated and Suppresses Colorectal Cancer Growth and Tumor Metastasis by Antagonizing Wnt/β-Catenin Signaling | Zendy

Can Wang | Zendy; Yujuan Yue | Zendy; Bianfei Shao | Zendy; Zhu Qiu | Zendy; Junhao Mu | Zendy; Jun Tang | Zendy; Xiaofan Han | Zendy; Tingxiu Xiang | Zendy; Guosheng Ren | Zendy

Open Access

Dickkopf-Related Protein 2 is Epigenetically Inactivated and Suppresses Colorectal Cancer Growth and Tumor Metastasis by Antagonizing Wnt/β-Catenin Signaling

Author(s) -

Can Wang,

Yujuan Yue,

Bianfei Shao,

Zhu Qiu,

Junhao Mu,

Jun Tang,

Xiaofan Han,

Tingxiu Xiang,

Guosheng Ren

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000471861

Subject(s) - wnt signaling pathway , ectopic expression , biology , cancer research , cell growth , cell cycle , gene silencing , dna methylation , epithelial–mesenchymal transition , metastasis , catenin , viability assay , signal transduction , cell , microbiology and biotechnology , cell culture , cancer , gene expression , genetics , gene

Aberrant activation of the Wnt/β-catenin signaling pathway plays a key role in the pathogenesis of multiple tumors including digestive cancers. Recent studies have reported that Dickkopf-related protein 2 (DKK2) is epigenetically inactivated in numerous types of cancers and that its gene products exhibit tumor-suppressive properties. However, the biological functions and underlying molecular mechanisms of DKK2 in colon carcinoma remains obscure.

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