In vitro and ex vivo Measurement of Prophylactic Dabigatran Concentrations with a New Ecarin-Based Thromboelastometry Test | Zendy

Mareike Kristina Körber | Zendy; Elisabeth Langer | Zendy; Martin Köhr | Zendy; Klaus–Dieter Wernecke | Zendy; Wolfgang Korte | Zendy; Christian von Heymann | Zendy

Open Access

In vitro and ex vivo Measurement of Prophylactic Dabigatran Concentrations with a New Ecarin-Based Thromboelastometry Test

Author(s) -

Mareike Kristina Körber,

Elisabeth Langer,

Martin Köhr,

Klaus–Dieter Wernecke,

Wolfgang Korte,

Christian von Heymann

Publication year - 2017

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000470622

Subject(s) - dabigatran , thromboelastometry , medicine , partial thromboplastin time , thrombin time , clotting time , direct thrombin inhibitor , activated clotting time , thrombin , ex vivo , anesthesia , whole blood , pharmacology , coagulation , in vivo , surgery , atrial fibrillation , platelet , warfarin , cardiopulmonary bypass , microbiology and biotechnology , biology

An increasing number of oral anticoagulants has been approved, including dabigatran etexilate (DE). DE is a direct thrombin inhibitor that requires no routine monitoring, but, if necessary (e.g. urgent surgery etc.), the diluted thrombin time measured with Hemoclot® has shown reliable results. So far, no point-of-care (PoC) assay is available to measure DE effects. The EcaTEM assay uses ecarin to initiate the coagulation cascade at the step of thrombin generation and measures the clotting time (CT) by thromboelastometry.

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