Autocrine VEGF and IL-8 Promote Migration via Src/Vav2/Rac1/PAK1 Signaling in Human Umbilical Vein Endothelial Cells | Zendy

Li Ju | Zendy; Zhiwen Zhou | Zendy; Bo Jiang | Zendy; Yue Lou | Zendy; Xirong Guo | Zendy

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Autocrine VEGF and IL-8 Promote Migration via Src/Vav2/Rac1/PAK1 Signaling in Human Umbilical Vein Endothelial Cells

Author(s) -

Li Ju,

Zhiwen Zhou,

Bo Jiang,

Yue Lou,

Xirong Guo

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000465389

Subject(s) - autocrine signalling , rac1 , microbiology and biotechnology , cell migration , umbilical vein , vascular endothelial growth factor , human umbilical vein endothelial cell , biology , vascular endothelial growth factor a , signal transduction , small interfering rna , endothelial stem cell , cancer research , cell , cell culture , transfection , biochemistry , vegf receptors , genetics , in vitro

Pro-angiogenic factors VEGF and IL-8 play a major role in modulating the migratory potential of endothelial cells. The goal of this study was to investigate the effect of autocrine VEGF and IL-8 in the form of self-conditioned medium (CM) on human umbilical vein endothelial cells (HUVECs).

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