Co-Activation of TGFβ and Wnt Signalling Pathways Abrogates EMT in Ovarian Cancer Cells | Zendy

Tulika Mitra | Zendy; Sib Sankar Roy | Zendy

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Co-Activation of TGFβ and Wnt Signalling Pathways Abrogates EMT in Ovarian Cancer Cells

Author(s) -

Tulika Mitra,

Sib Sankar Roy

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000464436

Subject(s) - epithelial–mesenchymal transition , wnt signaling pathway , cancer research , transforming growth factor , ovarian cancer , flow cytometry , signal transduction , chemistry , microbiology and biotechnology , mesenchymal stem cell , biology , metastasis , cancer , immunology , genetics

The aggressive property of ovarian cancer (OC) in terms of epithelial-mesenchymal transition (EMT), proliferation and metastasis are of major concern. Different growth factors including TGFβ are associated with regulating these molecular events but the underlying mechanisms remain unclear. The aim of this report is to decipher the regulation of EMT by co-activation of TGFβ and Wnt signalling cascades in gaining malignancy.

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