Kaempferol Modulates DNA Methylation and Downregulates DNMT3B in Bladder Cancer | Zendy

Wei Qiu | Zendy; Jun Lin | Zendy; Yichen Zhu | Zendy; Jian Zhang | Zendy; Liping Zeng | Zendy; Ming Su | Zendy; Ye Tian | Zendy

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Kaempferol Modulates DNA Methylation and Downregulates DNMT3B in Bladder Cancer

Author(s) -

Wei Qiu,

Jun Lin,

Yichen Zhu,

Jian Zhang,

Liping Zeng,

Ming Su,

Ye Tian

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000464435

Subject(s) - dna methylation , dnmt3b , methyltransferase , methylation , dna methyltransferase , bladder cancer , chemistry , microbiology and biotechnology , cancer research , biology , cancer , dna , genetics , biochemistry , gene expression , gene

Genomic DNA methylation plays an important role in both the occurrence and development of bladder cancer. Kaempferol (Kae), a natural flavonoid that is present in many fruits and vegetables, exhibits potent anti-cancer effects in bladder cancer. Similar to other flavonoids, Kae possesses a flavan nucleus in its structure. This structure was reported to inhibit DNA methylation by suppressing DNA methyltransferases (DNMTs). However, whether Kae can inhibit DNA methylation remains unclear.

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