YAP-1 Promotes Tregs Differentiation in Hepatocellular Carcinoma by Enhancing TGFBR2 Transcription | Zendy

Yé Fan | Zendy; Yangjuan Gao | Zendy; Jianhua Rao | Zendy; Ke Wang | Zendy; Feng Zhang | Zendy; Chuanyong Zhang | Zendy

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YAP-1 Promotes Tregs Differentiation in Hepatocellular Carcinoma by Enhancing TGFBR2 Transcription

Author(s) -

Yé Fan,

Yangjuan Gao,

Jianhua Rao,

Ke Wang,

Feng Zhang,

Chuanyong Zhang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000464380

Subject(s) - hepatocellular carcinoma , flow cytometry , transcription factor , cancer research , immunosuppression , in vitro , western blot , peripheral blood mononuclear cell , biology , chemistry , microbiology and biotechnology , immunology , gene , biochemistry

Immunosuppression is one of the hallmarks of cancer; however, its molecular mechanism remains unknown. In the present study, we sought to investigate the expression and activation of yes-associated protein 1 (YAP-1) and its roles in T cells within hepatocellular carcinoma (HCC).

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