Raf Kinase Inhibitor Protein Attenuates Ischemic-Induced Microglia Cell Apoptosis and Activation Through NF-κB Pathway | Zendy

Li Su | Zendy; Rongrong Zhang | Zendy; Yuanyuan Chen | Zendy; Zhenyu Zhu | Zendy; Chao Ma | Zendy

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Raf Kinase Inhibitor Protein Attenuates Ischemic-Induced Microglia Cell Apoptosis and Activation Through NF-κB Pathway

Author(s) -

Li Su,

Rongrong Zhang,

Yuanyuan Chen,

Zhenyu Zhu,

Chao Ma

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000464119

Subject(s) - microglia , gene knockdown , apoptosis , iκbα , microbiology and biotechnology , nf κb , annexin , signal transduction , programmed cell death , western blot , downregulation and upregulation , motility , kinase , chemistry , cancer research , medicine , biology , inflammation , immunology , biochemistry , gene

Acute ischemic stroke is one of the most important factors leading to disability and death with the characterization of accumulated neuron death and injured supportive neurovascular structures. Raf-1 kinase inhibitory protein (RKIP) is a key molecule in cell response to survival or death stimuli. However, the role of RKIP in stroke is worthy to be further studied.

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