The Hippo Signaling Pathway Regulates Ovarian Function via the Proliferation of Ovarian Germline Stem Cells
Author(s) -
Haifeng Ye,
Xiaoyan Li,
Tuochen Zheng,
Chuan Hu,
Zezheng Pan,
Jian Huang,
Jia Li,
Wei Li,
Yuehui Zheng
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000464113
Subject(s) - yap1 , hippo signaling pathway , biology , stem cell , small hairpin rna , homeobox protein nanog , microbiology and biotechnology , cancer research , signal transduction , embryonic stem cell , gene knockdown , apoptosis , transcription factor , genetics , gene , induced pluripotent stem cell
To improve the separation, identification and cultivation of ovarian germline stem cells (OGSCs), to clarify the relationship between the Hippo signaling pathway effector YAP1 and the proliferation and differentiation of OGSCs in vitro and to identify the major contribution of Hippo signaling to ovarian function.
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