High Glucose Induces Mouse Mesangial Cell Overproliferation via Inhibition of Hydrogen Sulfide Synthesis in a TLR-4-Dependent Manner | Zendy

Tao Ding | Zendy; Wei Chen | Zendy; Juan Li | Zendy; Jiarong Ding | Zendy; Xiaobin Mei | Zendy; Haiyan Hu | Zendy

Open Access

High Glucose Induces Mouse Mesangial Cell Overproliferation via Inhibition of Hydrogen Sulfide Synthesis in a TLR-4-Dependent Manner

Author(s) -

Tao Ding,

Wei Chen,

Juan Li,

Jiarong Ding,

Xiaobin Mei,

Haiyan Hu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000461483

Subject(s) - mesangial cell , pi3k/akt/mtor pathway , cell growth , protein kinase b , viability assay , chemistry , biology , signal transduction , microbiology and biotechnology , cell , biochemistry , in vitro

Overproliferation of mesangial cells was believed to play an important role in the progress of diabetic nephropathy, one of the primary complications of diabetes. Hydrogen sulfide (H2S), a well-known and pungent gas with the distinctive smell of rotten eggs, was discovered to play a protective role in diabetic nephropathy.

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