Luteolin Enhances Sarcoplasmic Reticulum Ca2+-ATPase Activity through p38 MAPK Signaling thus Improving Rat Cardiac Function after Ischemia/Reperfusion | Zendy

Shasha Zhu | Zendy; Tongda Xu | Zendy; Yuanyuan Luo | Zendy; Yingying Zhang | Zendy; Haochen Xuan | Zendy; Yanfeng Ma | Zendy; Defeng Pan | Zendy; Dongye Li | Zendy; Zhu Hong | Zendy

Open Access

Luteolin Enhances Sarcoplasmic Reticulum Ca2+-ATPase Activity through p38 MAPK Signaling thus Improving Rat Cardiac Function after Ischemia/Reperfusion

Author(s) -

Shasha Zhu,

Tongda Xu,

Yuanyuan Luo,

Yingying Zhang,

Haochen Xuan,

Yanfeng Ma,

Defeng Pan,

Dongye Li,

Zhu Hong

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000460837

Subject(s) - phospholamban , cardioprotection , apoptosis , p38 mitogen activated protein kinases , tunel assay , endoplasmic reticulum , microbiology and biotechnology , pharmacology , ischemia , mapk/erk pathway , chemistry , reperfusion injury , phosphorylation , medicine , biology , biochemistry

A major challenge for current therapeutic strategies against ischemia/reperfusion (I/R) is the lack of effective drugs. Considering luteolin enhances the activity of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) to improve the systolic/diastolic function of rat hearts and cardiomyocytes during the I/R process, we studied the regulatory function of the p38 MAPK pathway in this protective mechanism.

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