Extracorporal Shock Waves Activate Migration, Proliferation and Inflammatory Pathways in Fibroblasts and Keratinocytes, and Improve Wound Healing in an Open-Label, Single-Arm Study in Patients with Therapy-Refractory Chronic Leg Ulcers | Zendy

I. Aschermann | Zendy; Seema Noor | Zendy; Sascha Venturelli | Zendy; Tobias Sinnberg | Zendy; Christian Busch | Zendy; Christian D. Mnich | Zendy

Open Access

Extracorporal Shock Waves Activate Migration, Proliferation and Inflammatory Pathways in Fibroblasts and Keratinocytes, and Improve Wound Healing in an Open-Label, Single-Arm Study in Patients with Therapy-Refractory Chronic Leg Ulcers

Author(s) -

I. Aschermann,

Seema Noor,

Sascha Venturelli,

Tobias Sinnberg,

Christian Busch,

Christian D. Mnich

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000460503

Subject(s) - wound healing , medicine , cell migration , chronic wound , in vivo , cell growth , fibroblast , cell , pathology , cancer research , surgery , in vitro , biology , biochemistry , microbiology and biotechnology , genetics

Chronic leg ulcers (CLUs) are globally a major cause of morbidity and mortality with increasing prevalence. Their treatment is highly challenging, and many conservative, surgical or advanced therapies have been suggested, but with little overall efficacy. Since the 1980s extracorporal shock wave therapy (ESWT) has gained interest as treatment for specific indications. Here, we report that patients with CLU showed wound healing after ESWT and investigated the underlying molecular mechanisms.

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