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Baicalin Attenuates Cardiac Dysfunction and Myocardial Remodeling in a Chronic Pressure-Overload Mice Model
Author(s) -
Yanqing Zhang,
Pingping Liao,
Meng’en Zhu,
Wei Li,
Dan Hu,
Siming Guan,
Long Chen
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000459708
Subject(s) - baicalin , medicine , pressure overload , fibrosis , myocardial fibrosis , cardiac function curve , cardiac fibrosis , muscle hypertrophy , cardiology , endocrinology , heart failure , cardiac hypertrophy , chemistry , high performance liquid chromatography , chromatography
Baicalin has been shown to be effective for various animal models of cardiovascular diseases, such as pulmonary hypertension, atherosclerosis and myocardial ischaemic injury. However, whether baicalin plays a role in cardiac hypertrophy remains unknown. Here we investigated the protective effects of baicalin on cardiac hypertrophy induced by pressure overload and explored the potential mechanisms involved.

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