Phototoxicity of Doxycycline: A Systematic Review on Clinical Manifestations, Frequency, Cofactors, and Prevention | Zendy

Steven Goetze | Zendy; Christian Hiernickel | Zendy; Peter Elsner | Zendy

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Phototoxicity of Doxycycline: A Systematic Review on Clinical Manifestations, Frequency, Cofactors, and Prevention

Author(s) -

Steven Goetze,

Christian Hiernickel,

Peter Elsner

Publication year - 2017

Publication title -

skin pharmacology and physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.703

H-Index - 74

eISSN - 1660-5535

pISSN - 1660-5527

DOI - 10.1159/000458761

Subject(s) - phototoxicity , doxycycline , medicine , cofactor , dermatology , pharmacology , antibiotics , chemistry , biochemistry , enzyme , in vitro

One of the most important dermatologic side effects of doxycycline is photosensitivity. As doxycycline is important for malaria prophylaxis and malaria is mainly spread in countries with high sun radiation, special attention should be paid to this adverse effect. While there are many publications on the phototoxicity of tetracyclines in general, only a few exist focusing on doxycycline. The objective of this systematic review was to summarize all available reports on clinical manifestations, influencing factors like UV dose or dose of medication, and the possibilities of prevention by sun protection.

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