Lysophosphatidic Acid Promotes Epithelial to Mesenchymal Transition in Ovarian Cancer Cells by Repressing SIRT1 | Zendy

Upasana Ray | Zendy; Sib Sankar Roy | Zendy; Shreya Chowdhury | Zendy

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Lysophosphatidic Acid Promotes Epithelial to Mesenchymal Transition in Ovarian Cancer Cells by Repressing SIRT1

Author(s) -

Upasana Ray,

Sib Sankar Roy,

Shreya Chowdhury

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000458744

Subject(s) - lysophosphatidic acid , epithelial–mesenchymal transition , mesenchymal stem cell , ovarian cancer , microbiology and biotechnology , chemistry , cancer research , epithelial ovarian cancer , transition (genetics) , cancer , medicine , biology , biochemistry , gene , receptor

Epithelial-to-mesenchymal transition (EMT) plays an essential role in the transition from early to invasive phenotype, however the underlying mechanisms still remain elusive. Herein, we propose a mechanism through which the class-III deacetylase SIRT1 regulates EMT in ovarian cancer (OC) cells.

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