Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation | Zendy

Ying Zong | Zendy; Shijie Feng | Zendy; Jin-Wei Cheng | Zendy; ChenLin Yu | Zendy; Lu GuoCai | Zendy

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Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation

Author(s) -

Ying Zong,

Shijie Feng,

Jin-Wei Cheng,

ChenLin Yu,

Lu GuoCai

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000458742

Subject(s) - atf4 , transfection , hek 293 cells , apoptosis , biology , microbiology and biotechnology , cell growth , viability assay , cell , cell culture , cancer research , unfolded protein response , biochemistry , genetics

Activating transcription factor 4 (ATF4) is a member of the activating transcription factor family which regulates the expression of genes involved in amino acid metabolism, redox homeostasis and ER stress responses. ATF4 is also over-expressed in human solid tumors, although its effect on responsiveness to radiation is largely unexplored.

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