Kidney Injury Molecule-1 is Elevated in Nephropathy and Mediates Macrophage Activation via the Mapk Signalling Pathway | Zendy

Lei Tian | Zendy; Xinghua Shao | Zendy; Yuanyuan Xie | Zendy; Qin Wang | Zendy; Xiajing Che | Zendy; Minfang Zhang | Zendy; Weijia Xu | Zendy; Yao Xu | Zendy; Shan Mou | Zendy; Zhaohui Ni | Zendy

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Kidney Injury Molecule-1 is Elevated in Nephropathy and Mediates Macrophage Activation via the Mapk Signalling Pathway

Author(s) -

Lei Tian,

Xinghua Shao,

Yuanyuan Xie,

Qin Wang,

Xiajing Che,

Minfang Zhang,

Weijia Xu,

Yao Xu,

Shan Mou,

Zhaohui Ni

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000458737

Subject(s) - acute kidney injury , kidney , kidney disease , mapk/erk pathway , macrophage , medicine , urinary system , nephropathy , pathology , fibrosis , cancer research , endocrinology , biology , kinase , in vitro , microbiology and biotechnology , biochemistry , diabetes mellitus

Kidney injury molecule-1 (KIM-1) is highly expressed in renal tubular cells after injury and is usually regarded as an early biomarker of acute kidney injury(AKI). The aim of this study was to determine the role of KIM-1 in the development of renal tubular injury Methods: Clinical samples, three different animal models and in vitro experiments were utilized to determine the possible mechanism underlying the involvement of KIM-1 in kidney injury.

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