Inhibition of Methylglyoxal-Induced AGEs/RAGE Expression Contributes to Dermal Protection by N-Acetyl-L-Cysteine | Zendy

Chuntao Yang | Zendy; Fuhui Meng | Zendy; Li Chen | Zendy; Xiang Li | Zendy; Laijian Cen | Zendy; Yuhua Wen | Zendy; Hui Zhang | Zendy; Caichen Li | Zendy

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Inhibition of Methylglyoxal-Induced AGEs/RAGE Expression Contributes to Dermal Protection by N-Acetyl-L-Cysteine

Author(s) -

Chuntao Yang,

Fuhui Meng,

Li Chen,

Xiang Li,

Laijian Cen,

Yuhua Wen,

Hui Zhang,

Caichen Li

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000458734

Subject(s) - methylglyoxal , glycation , hacat , rage (emotion) , chemistry , reactive oxygen species , glutathione , viability assay , inflammation , pharmacology , matrix metalloproteinase , biochemistry , immunology , medicine , cell , receptor , biology , in vitro , enzyme , neuroscience

Accumulation of advanced glycation end products (AGEs) is a major cause of diabetes mellitus (DM) skin complications. Methylglyoxal (MGO), a reactive dicarbonyl compound, is a crucial intermediate of AGEs generation. N-acetyl-L-cysteine (NAC), an active ingredient of some medicines, can induce endogenous GSH and hydrogen sulfide generation, and set off a condensation reaction with MGO. However, there is rare evidence to show NAC can alleviate DM-induced skin injury through inhibition of AGEs generation or toxicity. The present study aimed to observe the effects of NAC on MGO-induced inflammatory injury and investigate the roles of AGEs and its receptor (RAGE) in NAC's dermal protection in human HaCaT keratinocytes.

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