Hepatitis B Virus X Protein Reduces Podocyte Adhesion via Downregulation of α3β1 Integrin | Zendy

Ping He | Zendy; Dajun Liu | Zendy; Beiru Zhang | Zendy; Guangyu Zhou | Zendy; Xuesong Su | Zendy; Yanqiu Wang | Zendy; Detian Li | Zendy; Yang Xu | Zendy

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Hepatitis B Virus X Protein Reduces Podocyte Adhesion via Downregulation of α3β1 Integrin

Author(s) -

Ping He,

Dajun Liu,

Beiru Zhang,

Guangyu Zhou,

Xuesong Su,

Yanqiu Wang,

Detian Li,

Yang Xu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000458428

Subject(s) - downregulation and upregulation , podocyte , integrin , microbiology and biotechnology , adhesion , virology , hepatitis b virus , chemistry , virus , medicine , biology , proteinuria , biochemistry , kidney , receptor , gene , organic chemistry

Hepatitis B virus (HBV)-associated glomerulonephritis (HBV-GN) is characterized by a reduced number of podocytes due to apoptosis and shedding from the basement membrane. However, the pathological mechanism of HBV-GN is unclear. We previously showed that hepatitis B virus X protein (HBx) promotes apoptosis in tubular epithelial cells. In this study, we transfected podocytes with HBx and examined the effects on adhesion and apoptosis of these cells.

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