Contribution of p62 to Phenotype Transition of Coronary Arterial Myocytes with Defective Autophagy | Zendy

JunXiang Bao | Zendy; Guangbi Li | Zendy; Xinxu Yuan | Zendy; PinLan Li | Zendy; Erich Gulbins | Zendy

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Contribution of p62 to Phenotype Transition of Coronary Arterial Myocytes with Defective Autophagy

Author(s) -

JunXiang Bao,

Guangbi Li,

Xinxu Yuan,

PinLan Li,

Erich Gulbins

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000457877

Subject(s) - gene silencing , cyclin dependent kinase 1 , cd38 , microbiology and biotechnology , cell cycle , sequestosome 1 , biology , autophagy , chemistry , cell , apoptosis , gene , cd34 , biochemistry , stem cell

Autophagy disorder contributes to dedifferentiation of arterial smooth muscle cells, but the mechanisms are poorly understood. Here, we sought to investigate the role of scaffolding adaptor p62/SQSTM1 (p62) in phenotype switching of mouse coronary arterial myocytes (CAMs) induced by CD38 gene deficiency or lysosomal dysfunction which blocks autophagic flux in the cells.

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