Open AccessNext-Generation Sequencing Reveals a Nonsense Mutation (p.Arg364Ter) in MRE11A Gene in an Indian Patient with Familial Breast Cancer
Author(s) -
Pratibha Bhai,
Deepak Sharma,
Renu Saxena,
Ishwar C. Verma
Publication year - 2017
Publication title -
breast care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.767
H-Index - 30
eISSN - 1661-3805
pISSN - 1661-3791
DOI - 10.1159/000457786
Subject(s) - breast cancer , medicine , gene , mutation , genetics , nonsense mutation , cancer research , cancer , biology , missense mutation
The MRN complex consisting of MRE11A-RAD50-NBS1 proteins is involved in the repair of double-strand breaks, and mutations in genes coding for the MRN complex have been identified in families with breast and ovarian cancer.
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