MiR-125b Regulates the Osteogenic Differentiation of Human Mesenchymal Stem Cells by Targeting BMPR1b | Zendy

Huaqing Wang | Zendy; Zhao Xie | Zendy; Tianyong Hou | Zendy; Zhiqiang Li | Zendy; Ke Huang | Zendy; Jicheng Gong | Zendy; Wei Zhou | Zendy; Kanglai Tang | Zendy; Jianzhong Xu | Zendy; Shiwu Dong | Zendy

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MiR-125b Regulates the Osteogenic Differentiation of Human Mesenchymal Stem Cells by Targeting BMPR1b

Author(s) -

Huaqing Wang,

Zhao Xie,

Tianyong Hou,

Zhiqiang Li,

Ke Huang,

Jicheng Gong,

Wei Zhou,

Kanglai Tang,

Jianzhong Xu,

Shiwu Dong

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000457013

Subject(s) - mesenchymal stem cell , microbiology and biotechnology , alkaline phosphatase , osteoblast , microrna , cellular differentiation , western blot , chemistry , bone morphogenetic protein 2 , stem cell , biology , gene , in vitro , biochemistry , enzyme

Osteogenic differentiation of mesenchymal stem cells (MSCs) plays a crucial role in bone regeneration and bone reparation. This complex process is regulated precisely and firmly by specific factors. Recent studies have demonstrated that miR-125b regulates osteogenic differentiation, but little is known about the molecular mechanisms of this regulation. Furthermore, how miR-125b regulates the osteogenic differentiation of MSCs still needs elucidation.

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