NEL-Like Molecule-1 (Nell1) Is Regulated by Bone Morphogenetic Protein 9 (BMP9) and Potentiates BMP9-Induced Osteogenic Differentiation at the Expense of Adipogenesis in Mesenchymal Stem Cells | Zendy

Jing Wang | Zendy; Junyi Liao | Zendy; Fugui Zhang | Zendy; Dongzhe Song | Zendy; Minpeng Lu | Zendy; Jianxiang Liu | Zendy; Qiang Wei | Zendy; Shengli Tang | Zendy; Hao Liu | Zendy; Jiaming Fan | Zendy; Yulong Zou | Zendy; Dan Guo | Zendy; Jiayi Huang | Zendy; Feng Liu | Zendy; Chao Ma | Zendy; Xue Hu | Zendy; Li Li | Zendy; Xiangyang Qu | Zendy; Liqun Chen | Zendy; Yaguang Weng | Zendy; Michael J. Lee | Zendy; TongChuan He | Zendy; Russell R. Reid | Zendy; Jiye Zhang | Zendy

Open Access

NEL-Like Molecule-1 (Nell1) Is Regulated by Bone Morphogenetic Protein 9 (BMP9) and Potentiates BMP9-Induced Osteogenic Differentiation at the Expense of Adipogenesis in Mesenchymal Stem Cells

Author(s) -

Jing Wang,

Junyi Liao,

Fugui Zhang,

Dongzhe Song,

Minpeng Lu,

Jianxiang Liu,

Qiang Wei,

Shengli Tang,

Hao Liu,

Jiaming Fan,

Yulong Zou,

Dan Guo,

Jiayi Huang,

Feng Liu,

Chao Ma,

Xue Hu,

Li Li,

Xiangyang Qu,

Liqun Chen,

Yaguang Weng,

Michael J. Lee,

TongChuan He,

Russell R. Reid,

Jiye Zhang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000456885

Subject(s) - adipogenesis , mesenchymal stem cell , microbiology and biotechnology , ectopic expression , bone morphogenetic protein 7 , bone morphogenetic protein 2 , in vivo , chemistry , bone morphogenetic protein , biology , in vitro , biochemistry , gene

BMP9 induces both osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs). Nell1 is a secretory glycoprotein with osteoinductive and anti-adipogenic activities. We investigated the role of Nell1 in BMP9-induced osteogenesis and adipogenesis in MSCs.

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