Higher Numbers of T-Bet+ Tumor-Infiltrating Lymphocytes Associate with Better Survival in Human Epithelial Ovarian Cancer | Zendy

Yun Xu | Zendy; Lujun Chen | Zendy; Bin Xu | Zendy; Yuqi Xiong | Zendy; Min Yang | Zendy; Xiaohui Rui | Zendy; Liangrong Shi | Zendy; Changping Wu | Zendy; Jingting Jiang | Zendy; Binfeng Lu | Zendy

Open Access

Higher Numbers of T-Bet+ Tumor-Infiltrating Lymphocytes Associate with Better Survival in Human Epithelial Ovarian Cancer

Author(s) -

Yun Xu,

Lujun Chen,

Bin Xu,

Yuqi Xiong,

Min Yang,

Xiaohui Rui,

Liangrong Shi,

Changping Wu,

Jingting Jiang,

Binfeng Lu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000456600

Subject(s) - tumor microenvironment , cd8 , tumor infiltrating lymphocytes , ovarian cancer , flow cytometry , metastasis , immunohistochemistry , pathology , cancer , immune system , immunotherapy , cd3 , cancer research , medicine , biology , immunology

T-bet, a member of the T-box family of transcription factors, is a key marker of type I immune response within the tumor microenvironment, and has been previously reported by us to serve as an important prognostic indicator for human gastric cancer patients and a potential biomarker for immunotherapy. In the present study, we aimed to assess the clinical significance and prognostic value of T-bet+ tumor-infiltrating lymphocytes in human epithelial ovarian cancer.

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