Adenovirus Vector Harboring the HBcAg and Tripeptidyl Peptidase II Genes Induces Potent Cellular Immune Responses In Vivo | Zendy

Quanhui Tan | Zendy; Siyuan Ma | Zendy; Jianjun Hu | Zendy; Xiaohua Chen | Zendy; Yu Yongsheng | Zendy; Zhenghao Tang | Zendy; Zang Guo-qin | Zendy

Open Access

Adenovirus Vector Harboring the HBcAg and Tripeptidyl Peptidase II Genes Induces Potent Cellular Immune Responses In Vivo

Author(s) -

Quanhui Tan,

Siyuan Ma,

Jianjun Hu,

Xiaohua Chen,

Yu Yongsheng,

Zhenghao Tang,

Zang Guo-qin

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000456579

Subject(s) - hbcag , biology , immune system , antigen , hepatitis b virus , antigen presentation , virology , immunology , hbsag , t cell , virus

Chronic hepatitis B virus (HBV) infection is associated with a weak but specific cellular immune response of the host to HBV. Tripeptidyl peptidaseⅡ (TPPⅡ), an intracellular macromolecule and proteolytic enzyme, plays an important complementary and compensatory role for the proteasome during viral protein degradation and major histocompatibility complex class I antigen presentation by inducing a specific cellular immune response in vivo. Based on a previous study, we aimed to explore the role of MHC class I antigen presentation in vivo and the mechanisms that may be involved.

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