Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection | Zendy

Nadine Honke | Zendy; Namir Shaabani | Zendy; Cornelia Hardt | Zendy; Caroline Krings | Zendy; Dieter Häussinger | Zendy; Philipp A. Lang | Zendy; Karl S. Lang | Zendy; Verena Keitel | Zendy

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Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection

Author(s) -

Nadine Honke,

Namir Shaabani,

Cornelia Hardt,

Caroline Krings,

Dieter Häussinger,

Philipp A. Lang,

Karl S. Lang,

Verena Keitel

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000456168

Subject(s) - farnesoid x receptor , lymphocytic choriomeningitis , nuclear receptor , receptor , biology , enterohepatic circulation , downregulation and upregulation , endocrinology , medicine , immunology , immune system , bile acid , biochemistry , cd8 , transcription factor , gene

Bile acids (BAs) are steroid molecules that are synthesized in the liver. In addition to their important role as a surfactant in solubilizing lipids and promoting the absorption of lipids in the gastrointestinal tract, they act as inflammagens. The role of BAs and their receptor farnesoid X receptor (FXR) during viral infection has not been studied in detail.

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