MicroRNA-141 Targets Sirt1 and Inhibits Autophagy to Reduce HBV Replication | Zendy

Ying Yang | Zendy; Yanning Liu | Zendy; Jihua Xue | Zendy; Zhenggang Yang | Zendy; Yu Shi | Zendy; Yixian Shi | Zendy; Guohua Lou | Zendy; Shanshan Wu | Zendy; Jinjin Qi | Zendy; Weixia Liu | Zendy; Zhi Chen | Zendy

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MicroRNA-141 Targets Sirt1 and Inhibits Autophagy to Reduce HBV Replication

Author(s) -

Ying Yang,

Yanning Liu,

Jihua Xue,

Zhenggang Yang,

Yu Shi,

Yixian Shi,

Guohua Lou,

Shanshan Wu,

Jinjin Qi,

Weixia Liu,

Zhi Chen

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000456162

Subject(s) - autophagy , microrna , microbiology and biotechnology , replication (statistics) , biology , cancer research , chemistry , virology , apoptosis , genetics , gene

About 400 million individuals are chronically infected with hepatitis B virus, at high risk of developing liver cirrhosis and hepatocellular carcinoma. Recent studies have demonstrated an interaction between hepatitis B virus replication and autophagy activity of hepatocytes. In the present study, we aimed to investigate the role of miR-141 in regulating autophagy and hepatitis B virus replication.

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